2016 Fiscal Year Final Research Report
Migration of mitochondria and nuclei in cell culture
| Project/Area Number |
15K12677
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Fukuoka University |
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Principal Investigator |
Higaki Yasuki 福岡大学, スポーツ科学部, 教授 (10228702)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ミトコンドリア |
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| Outline of Final Research Achievements |
Insulin resistance is associated with high levels of stored lipids in skeletal muscle cells. Fat storage in skeletal muscle from endurance athlete is higher than that in obese people. However, it is not clear why enhanced insulin sensitivity is observed in endurance athletes who had high lipid storage in skeletal muscle.
In this study we observed that mitochondria and lipid droplet are existed around nucleus, and nucleus and mitochondria go around lipid droplet in human induced pluripotent stem cells-derived myocytes. We speculate that localization of mitochondria and lipid droplet in skeletal muscle cells may be associated with insulin resistance.
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| Free Research Field |
運動生理学
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