Identification of substances in vivo that increase virus growth in a healthy human body

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K12680
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Okayama University
• Principal Investigator: Arao Yujiro 岡山大学, 保健学研究科, 教授 (40151146)
• Research Collaborator: KANEYUKI Masumi ; MIYAZAKI Makoto ; SAKURAI Sae ; TSUJI Hiroki ; MATSUMOTO Kaho ; TAKIZAWA Emi ; ABE Mizuki ; TAKADA Haruka ; MURAYAMA Chisa ; WATANABE Taiga
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 健常人 / 唾液 / 持続感染ウイルス / トルケテノウイルス / ヒトヘルペスウイルス６型 / nested real-time PCR / 炎症関連因子 / ストレス応答因子

Outline of Final Research Achievements

I tried to obtain clues to prevent the onset and advancing in severity of viral diseases. I collected saliva at rest from three healthy young adult subjects as specimens. I quantified Torque teno virus (TTV) DNA, human herpesvirus type 6 (HHV 6) DNA, inflammation-related factors, and stress-responsive factors in these specimens and then, searched host factors correlated with TTV or HHV6 DNA.
In one subject, there was a negative correlation between TTV DNA and alpha-amylase and there were weak negative correlations between TTV DNA and both secretory IgA and estradiol. In two of three subjects, I found weak negative correlations between the three substances in vivo and TTV DNA. Thus, it was speculated that the substances are likely to be associated with TTV DNA excreted in healthy human saliva.

Free Research Field

ウイルス学