2016 Fiscal Year Final Research Report
The mechanism of NASH development via long chain fatty acid receptor GPR120/FFAR4.
Project/Area Number |
15K12715
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | Kobe Gakuin University |
Principal Investigator |
OBATA TOKIO 神戸学院大学, 薬学部, 講師 (80625244)
|
Co-Investigator(Renkei-kenkyūsha) |
HIRASAWA Akira 京都大学, 大学院・薬学研究科, 准教授 (70242633)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 非アルコール性脂肪性肝炎(NASH) / GPR120/FFAR4 / DHA / fatty acid |
Outline of Final Research Achievements |
We investigated the involvement of long chain fatty acid receptor GPR120/FFAR4 in the progression of nonalcoholic steatohepatitis (NASH). We used choline-deficient and 0.1% methionine added high-fat diet (CDAHFD) in order to produce NASH pathology. In CDAHFD-induced NASH model mice, the liver cell injury, hepatic fat deposit, hepatic inflammation and fibrosis markers significantly increased, but these were suppressed by administration of DHA, an agonist of GPR120/FFAR4. On the other hand, GPR120/FFAR4 knockout mice further exacerbated hepatocyte damage and inflammation by CDAHFD-induced. These findings suggested that GPR 120/FFAR 4 is involved the development of NASH and DHA suppresses in progression.
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Free Research Field |
臨床薬学
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