2017 Fiscal Year Final Research Report
Paradigm shift of the mechanisms that development of higher brain function on maternofetal transmission
| Project/Area Number |
15K12728
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
遠藤 整 東海大学, 医学部, 講師 (10550551)
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| Research Collaborator |
ETO Tomoo
OWADA Satoshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 母体環境 / THAラット |
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| Outline of Final Research Achievements |
While embryos transfer to recipient females is a useful experimental technique for biology and experimental animal research, it has yet to be determined whether these artificial reproduction technique and the maternal factor affect the phenotype of offspring, especially higher brain function. We showed that high learning ability of Tokai high avoider (THA) rat offspring was not replicate by embryos transfer technique utilizing surrogate female Wistar rats that are low avoidance phenotype. However, a postnatal cross-fostering investigation with the offspring of Wistar rat and THA rat showed that maternal care such as postnatal behavior and lactation trait were not much difference between dams of low avoidance Wistar rat and THA rat. We conclude that the offspring phenotype, although unchanged, has an imperceptible effect on the learning ability of embryos transfer-derived THA rats through the intrauterine environment of the recipient.
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| Free Research Field |
予防医学
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