2016 Fiscal Year Final Research Report
Construction of convergent library for fungal cytochrome P450s and its application to exploring novel functions
| Project/Area Number |
15K12737
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MINAMI Atsushi 北海道大学, 大学院理学研究院, 助教 (40507191)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | チトクロームP450 / 酸化酵素 / 天然物 / 生合成 |
|---|
| Outline of Final Research Achievements |
Heterologous expression of cytochrome P450 for fungal natural product biosynthesis has been employed. We succeeded to prepare library of multiple P450-expressed transformants. Using this unique library, we performed the screening the transformants and found various conversion to generate a number of new metabolites although their productions were relatively low.
|
| Free Research Field |
生物有機化学
|
