2016 Fiscal Year Final Research Report
Studies on life span regulation by endogenous substances
| Project/Area Number |
15K12752
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 寿命制御機構 |
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| Outline of Final Research Achievements |
Recently, several endogenous substances have been reported to suppress aging of animals. In this study, we focused on endogenous compounds derived from nitric oxide, and studied its effects on life span extentions using nematode C. elegans. The lifespan extension effect depended on daf-16, skn-1 genes but not on daf-2 and eat-2 genes. The prolonged lifespan by the NO-derived compound was suppressed by knockdown of an autophagy-related gene atg5.
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| Free Research Field |
ケミカルバイオロジー
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