Development of new anchor molecule to fix biologically active molecules on cell surface

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K12758
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: Osaka City University
• Principal Investigator: Shinada Tetsuro 大阪市立大学, 大学院理学研究科, 教授 (30271513)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞膜 / 情報伝達 / 錨分子 / ドリコール

Outline of Final Research Achievements

To analyze biological events and signal transduction on cell surface, we envisioned a new anchor molecule to fix biologically active molecules on the cell surface. As a new anchor, we designed a dolichol analog with all trans olefins (C100). The designed molecule is not available from nature and has not been synthesized yet. Therefore, we attempted the first synthesis of the C100 anchor. After extensive studies, the target molecule was successfully synthesized by coupling of C45 and C55 units that was prepared by linkage of three C15 units and a C10 unit. Phosphorylation of the C100 anchor was attempted.

Free Research Field

天然物化学