Development of magnetoresponsive drug delivery carriers - Complex control of microstructure and superparamagnetic behavior

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K13298
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nanomaterials engineering
• Research Institution: Tohoku University
• Principal Investigator: Fujieda Shun 東北大学, 多元物質科学研究所, 助教 (60551893)
• Co-Investigator(Renkei-kenkyūsha): Balachandran Jeyadevan 滋賀県立大学, 工学部, 教授 (80261593)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ナノ粒子 / ドラックデリバリー / 酸化鉄

Outline of Final Research Achievements

Porous iron oxide particles have attached much attention for the application to magnetoresponsive drug delivery carriers, which can accelerate drug release by application of an alternating magnetic field due to heat generation of magnetic iron oxide particles. In this investigation, porous iron oxide particles with a capsule-like shape were synthesized from iron phosphate hydrate particles using alkaline solution. After heat treatment, porous iron oxide particles exhibited heat generation ability under alternating magnetic fields. In addition, needle-like shaped porous iron oxide particles with heat generation ability under alternating magnetic fields were successfully synthesized by heat treatment of iron oxyhydroxide particles.

Free Research Field

材料物性