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2015 Fiscal Year Final Research Report

Hemostatic material based on functional nanocarbon complexes

Research Project

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Project/Area Number 15K13309
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nanomaterials engineering
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Miyako Eijiro  国立研究開発法人産業技術総合研究所, ナノ材料研究部門, 主任研究員 (70443231)

Project Period (FY) 2015-04-01 – 2016-03-31
Keywordsカーボンナノチューブ / 光発熱特性 / 止血材料 / 近赤外光
Outline of Final Research Achievements

We describe a carbon nanotube-liposome-based supramolecular nanohybrid capable of permeation through cells with high biocompatibility. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near-infrared laser irradiation for the release of molecules from the nanohybrids in a targeted manner via microscopy. We implemented the controlled release of molecules from nanohybrids and demonstrated their efficacy in remote regulation of photo-induced nanohybrid functions. As a proof of principle, nanohybrids loaded with amiloride were successfully used in spatiotemporal blocking of targeted amiloride-sensitive mechanosensory neurons in living Caenorhabditis elegans. Our prototype could inspire new designs with biomimetic parasitism and symbiosis and biologically active nanorobots for higher-level manipulation of organisms.

Free Research Field

ナノバイオ工学

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Published: 2017-05-10  

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