Single-particle mass pspectroscopy by electrophoresis analyisis

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K13323
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nano/Microsystems
• Research Institution: Osaka University
• Principal Investigator: Tsutsui Makusu 大阪大学, 産業科学研究所, 准教授 (50546596)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: マイクロナノセンサー

Outline of Final Research Achievements

In this research an integrated nanostructure consisting of micropores, microfluidic channels, and nanoelectrodes were developed to investigate fast electrophoretic dynamics of individual particles in liquid via resistive pulse sensing. Particle translocation time was measured under cross-channel voltage for driving the electrophoretic motions while imposing transverse voltage to the embedded nanoelectrodes. Simultaneous measurements of the longitudinal ionic current and the transverse current showed concomitant change associated with blocking of ion transport via a particle passing through the fluidic channel, thereby demonstrating a possibility of using the novel fluidic channel sensor as a useful tool to study single-particle dynamics in liquid and its application for mass spectroscopy.

Free Research Field

ナノテクノロジー