2016 Fiscal Year Final Research Report
Evaluation of healthiness by in vivo broadband dielectric spectroscopy for water structures in living body
| Project/Area Number |
15K13554
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Water structure / Dielectric spectroscopy / Broadband dynamics / Living body / in vivo / Noninvasive testing / free water / Interfacial polaization |
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| Outline of Final Research Achievements |
Water structure analysis was performed for biological tissue models, such as standard liquids, ionic water flow, polymer gels, and emulsions, using broadband dielectric spectroscopy (BDS) and complementary techniques such as nuclear magnetic resonance and molecular dynamic simulation. The fractal analysis of dynamic hydrogen bonding network by BDS offers the water content, restrictions and dispersion of water molecules and ions. Furthermore, applications to cultured cells, organs from model mice, and the noninvasive test make it possible to distinguish organs obtained from robust and septic mice, respectively, and suggest a possibility of new bioinstrumentations and analytical methods. In future, applications should be expected in various areas of brain functions, medical care, and extensive areas of natural science and technology.
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| Free Research Field |
Biophysics
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