2016 Fiscal Year Final Research Report
Challenge to the formation of prebiotic RNA on mineral templates
Project/Area Number |
15K13588
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Petrology/Mineralogy/Economic geology
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KAKEGAWA TAKESHI 東北大学, 大学院理学研究科, 教授 (60250669)
NAGASE TOSHIRO 東北大学, 総合学術博物館, 准教授 (10237521)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 鉱物 / RNA / テンプレート / 重合 / リン酸化 / ヌクレオチド |
Outline of Final Research Achievements |
This study challenged the formation of oligonucleotides on mineral templates. Gypsum and calcite were used as the template mineral since they are ion crystal that potentially presented on the early Earth. Four kinds of adenosine nucleotides were investigated as the monomer of the oligomerization experiments. As the results, oligonucleotides were formed on gypsum template and glass template. However, the reproducibility of the results and the effects of template remain unclear. Thus, additional experiments are conducted. Further, a borophosohate mineral, luneburgite, was investigated as the source of phosphorus in phosphorylation of nucleoside and found that this mineral serves phosphate effectively and promote the formation of nucleotide in a potential prebiotic environment. This work was published in Angwandte Chemie International Edition as a very important paper.
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Free Research Field |
地球化学
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