2016 Fiscal Year Final Research Report
Analysis of Cell Response Mechanisms for Plasma Irradiation by Metabolic Model Simulation
| Project/Area Number |
15K13608
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plasma science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IKUSE Kazumasa 大阪大学, 工学研究科, 特任研究員 (20795778)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | プラズマ医療 / 活性酸素 / 酸化ストレス / 代謝反応ネットワーク / 数値シミュレーション / 代謝流速均衡解析 / ゲノムスケール代謝モデル / 大腸菌 |
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| Outline of Final Research Achievements |
We have constructed numerical simulation systems to examine the change in metabolic reactions (stress responses) of Escherichia coli (E. coli) under plasma irradiation. E. Coli is one of the most widely studied systems with Genome Scale Metabolic Models (GSMM). With our simulation model that evaluates oxidative stress generated by low-temperature atmospheric-pressure plasmas, we have established a methodology to determine the biological mechanisms for bactericidal effects by plasma application and clarified the inactivation process of E. coli by its change in metabolism caused by oxidative stress.
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| Free Research Field |
プラズマ物理学
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