2016 Fiscal Year Final Research Report
Functionalization of cytoskeletons by metal complexes
| Project/Area Number |
15K13661
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Inorganic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 細胞膜骨格 / 赤血球 / 金属錯体 |
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| Outline of Final Research Achievements |
In this study, we aimed to modify red blood cell cytoskeletons with metal complexes. We have succeeded in the synthesis of NHS ester derivatives of metal ligands, the optimization of reaction conditions between NHS ester derivatives of metal ligands and ghost Red Blood Cell (gRBC), and the formation of metal complexes on the cytoskeleton of gRBC modified with metal ligands. These results showed that the cytoskeleton of gRBC provided a useful platform for immobilization of metal complexes. Further efforts are in progress to elucidate the detail structure of gRBC cytoskeleton modified with metal complexes, and the physical properties of metal complexes on gRBC cytoskeleton.
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| Free Research Field |
無機化学
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