2017 Fiscal Year Final Research Report
Generation of metal-carbene species without using diazo-comoounds and its synthetic application
| Project/Area Number |
15K13686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
SHIGENO Daiki
MIYAZAWA Taku
TAKIZAWA Kouji
SUNADOI Yuta
SATAKE Shun
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 遷移金属触媒 / 遷移金属カルベン / 直接変換 / シクロプロパン / コバルト / ルテニウム |
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| Outline of Final Research Achievements |
We tried to develop new methods to generate transition metal-carbene species without using diazo compounds. We initially tried direct generation of the transition metal-carbene species from methylene compounds under oxidative conditions; but, all trials failed. Thus, we investigated alternative methods by using iodonium ylides as starting materials. In this case, the reaction proceeded smoothly. Therefore, we then turned our attention to develop new chiral catalysts for stereocontrol using iodonium ylides. After intensive investigation, we finally found chiral Ru complex was the best, giving cyclopropanes in up to 97% enantioselectivity.
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| Free Research Field |
合成化学
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