Development of New Nitrogen-Centered Radical Precursor and Photocatalytic Radical Amination

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K13689
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Koike Takashi 東京工業大学, 科学技術創成研究院, 助教 (30451991)
• Research Collaborator: MIYAZAWA Kazuki
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 光触媒 / アミノ化 / 窒素ラジカル / ラジカル反応 / 太陽光

Outline of Final Research Achievements

Photoredox catalysis has been regarded as a useful tool for radical reactions because it can catalyze single-electron-transfer processes under visible light irradiation. We have developed new nitrogen-centered radical precursors, 1-aminopyridinium salts and 1-iminopyridinium ylides. Photocatalytic aminohydroxylation of olefins, which results in production of useful 1,2-aminoalcohols, was achieved by combination of photoredox catalysis and new aminating reagents.

Free Research Field

有機合成化学