2016 Fiscal Year Final Research Report
Development of base metal catalyst bearing N4 and PNN ligand toward asymmetric hydrogenation
| Project/Area Number |
15K13693
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 卑金属触媒 |
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| Outline of Final Research Achievements |
Asymmetric hydrogenation is one of the reliable and practical tools to provide chiral materials. Starting from development of Noyori hydrogenation using Ru complex, this chemistry has been highly sophisticated to be nearly perfect reaction up to now. Under this stream, replacement of rare metals with base metals is an important subject from the view points of resources, cost, and safety. We have aimed to solve this problem on the basis of non-phosphine-type complex catalyst. We have developed two representative ligands, Ph-BINAN-H-Py and R-BINAN-Ph-PPh2, the Ru complexes of which show high performance in asymmetric hydrogenation of ketones. In this study, a series of base metal complexes of these ligands have been synthesized and their structures have been elucidated, establishing a basis for the future screening of base complexes.
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| Free Research Field |
有機合成化学
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