Challenge for Development of Catalytic Enantioselective Hydrofluorination and Hydrotrifluoromethylation of Alkenes

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K13696
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Osaka University
• Principal Investigator: Hirano Koji 大阪大学, 工学研究科, 准教授 (70532696)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: フッ素 / 銅触媒 / リン / 触媒的不斉合成

Outline of Final Research Achievements

The purpose of this research is development of highly challenging catalytic enantioselective hydrofluorination and hydrotrifluoromethylation of alkenes. While preliminary, we have developed a nonenantioselective copper-based catalyst system for the catalytic hydrofluorination of alkenes. To increase the catalytic performance and establish the enantioselective variant, we have also developed a new copper-catalyzed C-P bond-forming reaction for the synthesis of novel and highly active ligands. By this Cu catalysis, we can obtain bisphosphine-type ligands from simple and readily available terminal alkenes in one shot.

Free Research Field

有機合成化学