Synthsis of Silacarboxylic Acid Derivatives and Applications Thereof

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K13697
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Kyushu University
• Principal Investigator: Igawa Kazunobu 九州大学, 先導物質化学研究所, 助教 (80401529)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 有機ケイ素分子 / カルボン酸誘導体 / シラカルボン酸 / シラカルボン酸エステル

Outline of Final Research Achievements

In this study, a variety of silacarboxylic acids and its derivatives have been synthesized and their unique reactivity were disclosed. A novel efficient approach to the silacarboxylic acid esters was developed based on ozone oxidation of alkoxyvinylsilanes. The detail of the reaction mechanism was demonstrated by theoretical studies with computational approach, which revealed that 1,3-cycloelimination of primary ozonide is accelerated by inductive effect of alkoxy group on the alkene moiety. Moreover, asymmetric synthesis of alpha-hydroxy silacarboxylic acid was achieved.

Free Research Field

有機合成化学