2016 Fiscal Year Final Research Report
Development of the new palladium-catalyzed reactions including the construction of trifluoromethyl group by the intramolecular fluorine atom shift
| Project/Area Number |
15K13701
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | パラジウム / フッ素 / アミノ化 / アルキル化 / エーテル化 |
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| Outline of Final Research Achievements |
We examined the reaction of 2,3,3-trifluoroallylic esters with several nucleophiles, such as nitrogen, oxygen, or carbon nucleophiles, by palladium catalysts, then we succeeded in progressing the new types of reactions, which provides trifluoromethyl group possessing organic compounds, which were produced by the attack of nucleophiles on to C-2 position of allylic group, and sequential intramolecular fluorine atom shift. We further demonstrated this types of palladium-catalyzed reaction with several types of nucleophiles, and succeeded in obtaining several types of trifluoromethylenamines, trifluoromethyl group containing 3-substituted indole analogues, or trifluoromethyl group possessing enol ethers.
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| Free Research Field |
合成化学
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