Development of a highly sensitive detection method using hyperpolarized nuclear magnetic resonance and meso-spaces

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K13737
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Nonaka Hiroshi 東京大学, 大学院工学系研究科(工学部), 講師 (80579269)
• Research Collaborator: SANDO SHINSUKE 東京大学, 大学院工学系研究科, 教授 (20346084) ; IMKAURA YUKI 東京大学, 大学院工学系研究科化学生命工学専攻 ; ITO MAKOTO 東京大学, 工学部化学生命工学科
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 核磁気共鳴 / 核偏極 / 分子プローブ

Outline of Final Research Achievements

In this research, we have attempted to develop a new hyperpolarized sensing system utilizing a gated meso-space that can be loaded with a lot of hyperpolarized environmental-sensitive molecules. Meso-space is widely used in various fluorescence sensing systems utilizing environmental-sensitive fluorophores. To realize such sensing system, we have tried to explore environmental-sensitive hyperpolarized molecules for incorporating into a gated meso-space. We have found a promising signal molecule derived from [15N]glycine. It showed pH-dependent chemical shift change of its 15N nuclei. Moreover, it had a sufficient T1 value that was important parameter correlated with hyperpolarized lifetime. We expect that this finding would be valuable to develop a new sensing system in the field of hyperpolarized research.

Free Research Field

ケミカルバイオロジー