Study on the manipulation of microbubble-encapsulated vesicles using ultrasound field

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K13865
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: The University of Tokyo
• Principal Investigator: TAKAGI SHU 東京大学, 大学院工学系研究科(工学部), 教授 (30272371)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 混相流 / マイクロバブル / 超音波 / DDS / ベシクル / 表面修飾 / マイクロチャネル / バブルクラスター

Outline of Final Research Achievements

In this study, for the application of micro bubble DDS, we investigated the efficient method to generate microbubble-encapsulated vesicles. We further investigated the method to control the vesicle position and to break-up the vesicle membrane using ultrasound field. Both the experiments and simulations were conducted for the manipulation of vesicles. As results, it was shown that microbubble-encapsulated vesicles are very effectively generated by introducing Oil/Water Interface inverted emulsion method. For the vesicle manipulations, we succeeded to break-up the vesicles by manipulating bubbles using ultrasound field. The simulations were conducted to investigate the bubble size effect to the effective break-up of the vesicles.

Free Research Field

流体工学