Fabrication of drug-release type implant using amorphous calcium phosphate film as a carrier

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14142
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Composite materials/Surface and interface engineering
• Research Institution: Tohoku University
• Principal Investigator: Ueda Kyosuke 東北大学, 工学研究科, 准教授 (40507901)
• Co-Investigator(Renkei-kenkyūsha): KANETAKA Hiroyasu 東北大学, 大学院歯学研究科, 准教授 (50292222)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 生体材料 / 材料加工・処理 / 非晶質リン酸カルシウム / コーティング / 薬剤徐放 / 骨形成タンパク質

Outline of Final Research Achievements

Bone morphogenetic protein (BMP) was loaded on amorphous calcium phosphate (ACP) film by immersion in BMP-2 solution. The releasing behavior of BMP-2 from ACP film was evaluated. The amount of BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was higher than that with heparin. The BMP-2 loaded on ACP film by immersion in PBS(-) without heparin was released continuously for 12 h.

Free Research Field

医用材料工学