Development of an energy free drug delivery system using oxidative expansion of Fe powder

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14184
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Material processing/Microstructural control engineering
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: Yang Ming 首都大学東京, システムデザイン研究科, 教授 (90240142)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: マイクロ投薬システム / 金属粉末酸化 / マイクロ・ナノデバイス

Outline of Final Research Achievements

We developed an energy-free DDS which bases on oxidative expansion of Fe powder for transdermal dispensing of drug. The influential factors on oxidative expansion were investigated by using various kinds of Fe powders, and a prototype of micro pump was fabricated using molding of polymer. The results show that it is important to prevent aggregation and increase fluidity of Fe powder during the oxidation, and Fe powder mixed with lubricant powder of 1.0 wet % has good condition of aggregation-proof during oxidative expansion. The micro pump can pumping liquid with flow rate of 0.8 µl /min under the backpressure of 5 kPa. The results show that Fe powder has the potential to be a driving source instead of electrical energy for micro pump, and to be used as a transdermal dispensing of drugs.

Free Research Field

精密加工、マイクロデバイス創成