Development of solid catalysts for selective transformation of peptide chains by reductive cleavage

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14219
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Catalyst/Resource chemical process
• Research Institution: Tohoku University
• Principal Investigator: TAMURA Masazumi 東北大学, 工学研究科, 助教 (10635551)
• Co-Investigator(Renkei-kenkyūsha): TOMISHIGE Keiichi 東北大学, 大学院工学研究科, 教授 (50262051) ; NAKAGAWA Yoshinao 東北大学, 大学院工学研究科, 教授 (10436545)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 水素化 / アミド / ルテニウム / 酸化セリウム / 触媒 / ナノ粒子

Outline of Final Research Achievements

Protein(peptide) can be regarded as one of biomass-derived key materials, and can be obtained from green biomass. Therefore, development of transformation methods of protein is required. Dissociation of the amide bonds is one strategy for that, however, the methods that use stoichiometric amount of acids or bases are used as main ones, and alternative environmentally-benign methods are required. In this study, we investigated heterogeneous catalysts that enables direct cleavage of C-N bond in amide by hydrogenation, and found that N2-treated Ru/CeO2 catalyst showed high activity and selectivity for the reaction and that the small Ru particles over Ru/CeO2 are responsible active species for the high performance.

Free Research Field

触媒化学、有機化学