Development of fluorination catalysts generating metal oxo species as active species

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14226
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Catalyst/Resource chemical process
• Research Institution: Doshisha University
• Principal Investigator: Hitomi Yutaka 同志社大学, 理工学部, 教授 (20335186)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 鉄錯体 / 触媒 / フッ素化 / オキソ種

Outline of Final Research Achievements

Inspired by the reaction mechanism of mononuclear nonheme iron enzyme, SyrB2, which catalyzes direct halogenation of alkane C-H bonds under mild conditions, novel fluorination catalysts have been designed. SyrB2 generates nonheme oxoiron(IV) species as an active oxidant, which has a halogen ligand coordinated cis to the oxygen ligand. In order to reproduce the biological oxidant, new iron complexes that contain two cis-labile coordination sites have been synthesized. Some fluorinated products have been obtained using the catalysts under mild conditions.

Free Research Field

生物無機化学