2017 Fiscal Year Final Research Report
Development of fluorination catalysts generating metal oxo species as active species
Project/Area Number |
15K14226
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Catalyst/Resource chemical process
|
Research Institution | Doshisha University |
Principal Investigator |
Hitomi Yutaka 同志社大学, 理工学部, 教授 (20335186)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 鉄錯体 / 触媒 / フッ素化 / オキソ種 |
Outline of Final Research Achievements |
Inspired by the reaction mechanism of mononuclear nonheme iron enzyme, SyrB2, which catalyzes direct halogenation of alkane C-H bonds under mild conditions, novel fluorination catalysts have been designed. SyrB2 generates nonheme oxoiron(IV) species as an active oxidant, which has a halogen ligand coordinated cis to the oxygen ligand. In order to reproduce the biological oxidant, new iron complexes that contain two cis-labile coordination sites have been synthesized. Some fluorinated products have been obtained using the catalysts under mild conditions.
|
Free Research Field |
生物無機化学
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