Elucidation of the mechanism of modulation of synaptic transmission by the regulation of intracellular calcium release

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14309
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: The University of Tokyo
• Principal Investigator: Manabe Toshiya 東京大学, 医科学研究所, 教授 (70251212)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 神経科学 / 生理学 / 生体分子 / 脳・神経 / 遺伝子 / シナプス伝達 / 可塑性 / カルシウム

Outline of Final Research Achievements

In this study, we tried to elucidate roles of molecules that regulate calcium dynamics. We analyzed the functions of the molecules whose roles in calcium dynamics are not well known, using synapse site-specific gene-targeted mice. In the electrophysiological analysis with hippocampal slices, long-term potentiation of excitatory synaptic transmission was significantly reduced in postsynaptic site-specific Molecule A-deficient mice, whereas synaptic responses were increased during prolonged low-frequency stimulation in presynaptic terminal-specific Molecule A-deficient mice. We also found the possibility of the impairment in behavioral tests in Molecule B-deficient mice.

Free Research Field

神経科学