2016 Fiscal Year Final Research Report
Representation of motor learning and motor timing in the cerebellum
| Project/Area Number |
15K14312
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | システム神経生理学 / 小脳 / 運動制御 / 運動学習 |
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| Outline of Final Research Achievements |
Climbing fiber (CF) inputs to Purkinje cells carry error and/or timing signals for motor control and learning. CFs separately project to longitudinal clusters of Purkinje cells (cerebellar zones), which are characterized by the expression of aldolase C. We investigated the representation of CF inputs to the distinct cerebellar zones in Crus II of the cerebellar hemisphere by using two-photon calcium imaging in mice learning a go/no-go auditory discrimination task. CF inputs to the lateral aldolase C-positive zones were timed to the go cues and enhanced during the course of learning. Those to the lateral aldolase C-negative zones were timed only to the no-go cues, which declined along with learning. Those to the medial zones were longer in latency and showed lick-related representation. Our results indicate that differential and parallel processing of sensorimotor and cognitive information in the distinct cerebellar zones may collectively sophisticate goal-directed behavior.
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| Free Research Field |
神経生理学
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