Occurrence of anxiety through a specific neuronal group in the bed nucleus of stria terminlis

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14345
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Nagoya University (2016); The University of Tokyo (2015)
• Principal Investigator: Takemoto Sayaka (木村さやか) 名古屋大学, 環境医学研究所, 教授 (70372365)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 分界条床核 / カルシウム依存的リン酸化酵素 / 扁桃体中心核

Outline of Final Research Achievements

The occurrence of anxiety is modified by environment. One of the subcortical nucleus related to anxiety regulation is the bed nucleus of stria terminalis and the central nucleus of amygdala, which are included in the extended amygdala. In this study we focused on specific groups of neurons in these regions. We performed anatomical study to reveal connections between two regions. Furthermore, we established methods measuring and manipulating the neuronal groups in this area to understand the pathophysiology of anxiety disorders.

Free Research Field

分子神経科学