A study of DNA repair dynamics during neuronal differentiation using single-molecule imaging

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14350
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka University
• Principal Investigator: SUGO Noriyuki 大阪大学, 生命機能研究科, 助教 (20372625)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経細胞 / DNA損傷 / エピジェネティクス / 転写 / １分子イメージング

Outline of Final Research Achievements

DNA repair is an important mechanism in neuronal differentiation, in addition to transcription and chromatin regulation. Here, we examined DNA repair dynamics during neuronal differentiation using single-molecule imaging technique. We revealed the dynamics of DNA polymerase β, one of DNA repair enzymes, in the nucleus of cortical neurons.

Free Research Field

神経科学