Development of a novel therapy normalizing tumor-associated stroma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14385
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Juntendo University
• Principal Investigator: Akira Orimo 順天堂大学, 医学(系)研究科(研究院), 准教授 (70275866)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 癌微小環境 / ＣＡＦｓ / エピゲノム変異 / 乳癌

Outline of Final Research Achievements

CAFs（Carcinoma-associated fibroblasts）are often present in various human carcinomas. These fibroblasts are also composed of myofibroblasts, a hallmark of activated fibroblasts and known to promote tumor progression. However, molecular targets on CAFs have not been elucidated yet. In this study, we claim that HDAC inhibitors are a promising to inactivate tumor-promoting CAFs to prevent tumor progression.

Free Research Field

癌生物学