Analysis of tissue-intrinsic structure as the origin of tumorigenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14386
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: National Institute of Genetics
• Principal Investigator: Suzuki Emiko 国立遺伝学研究所, 構造遺伝学研究センター, 准教授 (20173891)
• Co-Investigator(Renkei-kenkyūsha): TAMORI Yoichiro 国立遺伝学研究所, 構造遺伝学研究センター, 助教 (10717325)
• Research Collaborator: TAIRA Kunihiko フロリダ州立大学, Dept. Mechanical Engineering, 准教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: がん微小環境 / 細胞競合 / ショウジョウバエ

Outline of Final Research Achievements

We previously found that neoplastic tumors in Drosophila imaginal discs always arise from the unique intrinsic structures "tumor hotspots" in the epithelial continuum. In the present study, we investigated the genetic mechanism underlying the cellular architecture of the tumor hotspots and the initiation of tumor formation, by the hydrodynamic modeling of epithelia we developed. We identified multiple candidate genes and enhancer elements potentially involved in the formation of hotspots. Furthermore, we found signaling pathways required for the delamination and proliferation of tumorigenic mutant epithelial cells at the hotspots.

Free Research Field

組織形態学