Aerobic glucose metabolism and Pkm1 in small cell lung cancer.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14387
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: ITO Shigemi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肺がん / Pkm / NAD代謝 / グルコース代謝

Outline of Final Research Achievements

In this study, we investigated whether cellular metabolism can be explored as novel therapeutic target of small cell lung cancer (SCLC). We found that neuroendocrine tumors, a subset of lung cancer, exhibit substantial expression of Pkm1. Functional analyses revealed that Pkm1, but not Pkm2, can fully support proliferation of the SCLC cell-lines, suggesting their dependence on Pkm1. We also found that an inhibitor on NAD salvage suppresses growth of PKM1-expressing cancer cells, suggesting a therapeutic strategy for PKM1-positive tumors such as SCLC

Free Research Field

腫瘍学