Analysis of the effects of the host environment factors on pancreatic cancer malignancy at whole body levels

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14393
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: National Cancer Center Japan
• Principal Investigator: Takahashi Mami 国立研究開発法人国立がん研究センター, 研究所, ユニット長 (90214973)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 膵臓がん / 動物モデル / 宿主環境要因 / 悪性化

Outline of Final Research Achievements

Five culture cell lines which develop well/moderately differentiated carcinoma grafts in C57BL/6J mice were established from pancreatic tumors of Ptfla(Cre/+)/LSL-K-ras(G12D/+) mice. When these cell lines were subcutaneously implanted to obese Ay mice, promotion of tumor growth was observed in 2 cell lines. Orthotopic implantation of the cells develop pancreatic tumor grafts in which marked fatty infiltration was observed, and dissemination to visceral fat. This orthotopic allograft model is useful to study the effects of pancreatic cancer risk factors such as obesity/diabetes on pancreatic tumor growth at whole body levels.

Free Research Field

発がん