2016 Fiscal Year Final Research Report
Clinical application of Imaging Mass-spectrometry in cancer fileld
| Project/Area Number |
15K14398
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Keio University |
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Principal Investigator |
Yasuda Hiroyuki 慶應義塾大学, 医学部(信濃町), 講師 (70365261)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 癌 / 血管新生阻害薬 / 代謝 |
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| Outline of Final Research Achievements |
The prognosis of cancer patients is poor. To improve the prognosis of cancer patients, variable approaches are necessary. Imaging mass-spectrometry (IMS) is a novel technology, which enables one to viisualize the distribution of hundreds of metabloite in tissues. Using this novel technology, we treid to clarify the mechansims of efficacy of some anti-cancer agents. We focused on anti-angiogenic agents such as nintedanib or bevacizumab. We partly clarified the mechanisms of efficacy of these agents by in vivo experiments with IMS. The findings will help developing an effective and appropriate treatement using anti-angiogenic agents.
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| Free Research Field |
癌
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