Reading cancer specific-metabolism signature from exosome

2015 Fiscal Year Final Research Report

• Project/Area Number: 15K14400
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnostics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Shiba Kiyotaka 公益財団法人がん研究会, その他部局等, その他 (40196415)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Keywords: エクソソーム / 細胞外分泌小胞 / P-糖タンパク質

Outline of Final Research Achievements

This research has confirmed that P-glycoprotein, which is known to be involved in multidrug resistance of cancer cell, is expressed on the exosomes that are released from the cells expressing P-glycoprotein. The conditions that allow specific fluorescence labelling of the P-glycoprotein-expressing exosomes using substrates of P-glycoprotein have been sought. However, sticky nature of exosomes under the assay conditions did not allow the establishment of the quantification method.

Free Research Field

生物学