Discovery of Cytotoxic T Lymphocyte-inspired Bacteria Machine for Cancer Therapeutic Use Based on Synthetic Biological Approach

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K14415
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Mukai Hidefumi 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60570885)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 細胞治療 / 合成生物学 / 細菌 / がん治療

Outline of Final Research Achievements

Bacterial cancer therapy, where bacteria are used as a gene expression system for exogenous protein of interest in bodies, starts to attract attention. The reports demonstrating the selective survival and growth of some anaerobes in tumor opened up the current trend of bacterial cancer therapy. Their transformants expressing different cytokines and suicide genes such as cytosine deaminase and herpes simplex virus-thymidine kinase were generated and evaluated on their anticancer effects as well as safety. In this study, we constructed cytotoxic T lymphocyte-inspired bacteria machine using cancer cell-selective ligands, etc.

Free Research Field

ドラッグデリバリー、分子イメージング