2017 Fiscal Year Final Research Report
A comprehensive genome-wide screen of radiosensitization targets
| Project/Area Number |
15K14416
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
MASUTANI Mitsuko 長崎大学, 医歯薬学総合研究科(医学系), 教授 (60238904)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
FUJIMORI Hiroaki 国立研究開発法人国立がん研究センター, 研究所, 研究員 (00590043)
|
|---|
| Research Collaborator |
ONODERA Takae
SASAKI Yuka
HIRAI Takahisa
IMAMICHI Shoji
KIKUHARA Sota
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | PARP / radiosensitization / DNMT3b / gamma-irradiation / cancer |
|---|
| Outline of Final Research Achievements |
A comprehensive genome-wide screen of radiosensitization targets in cancer cells using an shRNA-library has been performed and some genes were identified as candidate target. Among them, we focused on the DNMT3b, poly(ADP-ribose) polymerase1 (PARP-1)、interleukin 27 receptor, alpha (IL27RA) and APOBEC3G. These genes were suggested as potential targets of radiosensitization.
|
| Free Research Field |
薬学、生化学、腫瘍学、分子生物学
|
