2016 Fiscal Year Final Research Report
Development of the novel drug repositioning method based on disease genetics
| Project/Area Number |
15K14429
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical genome science
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| Research Institution | Osaka University (2016)
Tokyo Medical and Dental University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 遺伝統計学 / ドラッグ・リポジショニング / ゲノム創薬 |
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| Outline of Final Research Achievements |
In this study, we constructed an in silico analytical method that utilizes large scale human disease genome analysis results to efficiently identify novel therapeutic targets and candidates of drug repositioning. We collected drug and drug target gene information from multiple drug discovery databases. We also curated Anatomical Therapeutic Chemical (ATC) Classification System to list disease and approved drug lists. By applying the newly constructed method to the latest disease genetics study results of multiple human diseases including metabolic diseases, we empirically evaluated the value of our method.
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| Free Research Field |
遺伝統計学
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