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2016 Fiscal Year Final Research Report

Control of cell differentiation by the cytoplasmic pH change

Research Project

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Project/Area Number 15K14498
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biophysics
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Morimoto Yusuke  国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (50631777)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywordsシグナル伝達 / 細部内pH / 蛍光イメージング / 細胞分化 / 光遺伝学
Outline of Final Research Achievements

Intracellular pH plays important roles in the signal transduction for cell differentiation. However it remains unknown how intracellular pH change works in the cell differentiation. To investigate the role of intracellular pH, we constructed Dictyostelium discoideum strain expressing pH-sensitive fluorescent protein and observed cytoplasmic pH changes in the multicellular stage by fluorescence microscopy. And we could regulate the cytoplasmic pH of Dictyostelium cells expressing channelrhodopsin by photostimulation. We will try to control the cell differentiation by photostimulation.

Free Research Field

生物物理

URL: 

Published: 2018-03-22  

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