Identification of receptor for maturation-inducing hormone

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14504
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Ochanomizu University
• Principal Investigator: Kishimoto Takeo お茶の水女子大学, サイエンス&エデュケーションセンター, 客員教授 (00124222)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 卵成熟 / ホルモン受容体 / ヒトデ卵

Outline of Final Research Achievements

Oocyte maturation is a prerequisite for embryonic deveoplment after fertilization, whereas a putative oocyte surface receptor of maturation-inducing hormone has long been a major missing link. Here, we intended to identify the surface receptor in starfish oocytes through isolation of maturation-inducing hormone-binding protein. At present, we isolated and identified the protein complex that binds to starfish maturation-inducing hormone. However, it remains unclear whether the complex is actually involved in hormonal signaling that leads to oocyte maturation.

Free Research Field

細胞生物学