Regulation of cell division by arginine methylation and translation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14505
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Nagoya University
• Principal Investigator: Senga Takeshi 名古屋大学, 医学系研究科, 准教授 (80419431)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 細胞分裂 / アルギニンメチル化

Outline of Final Research Achievements

Failure in cell division induces cell death or cell transformation, so that cell division is regulated by various mechanisms. However, it still remain unknown how chromosomes are equally distributed during cell division.
We performed siRNA screening and found that PRMT1, a enzyme that methylates arginine, is essential for cell division. In addition, we found that arginine methylation of UBAP2L was required for equal distribution of chromosomes during cell division. We also found that G3BP and FXR1, which regulate translation, and small nucleolar RNA formed a large RNA-Protein complex with UBAP2L. Our results suggest that arginine methylation of UBAP2L complex may regulates cell division by promoting translation of speicific proteins for cell division.

Free Research Field

腫瘍医学