2017 Fiscal Year Final Research Report
Localized Wnt protein and morphogenesis.
| Project/Area Number |
15K14532
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
Mii Yusuke 基礎生物学研究所, 分子発生学研究部門, 助教 (70634129)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Wnt / 平面細胞極性 / Xenopus / ヘパラン硫酸 |
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| Outline of Final Research Achievements |
How Wnt proteins regulate morphogenesis and cell polarity is poorly understood. From visualization of Wnt11 in early Xenopus embryos, following possibilities are suggested. 1. Wnt11 shows different specificity for heparan sulfate from that of Wnt8. 2. Cell edges with Wnt11 accumulation tend to shrink. 3. For the regulation of planar cell polarity (PCP), Wnt11 appears to regulate amounts of core PCP components in a localized manner.
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| Free Research Field |
発生生物学 細胞生物学
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