Stress field estimation in three-dimensional optic-cup by image-based modeling

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14534
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Okuda Satoru 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 基礎科学特別研究員 (80707836)
• Co-Investigator(Renkei-kenkyūsha): EIRAKU Mototsugu 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, チームリーダー (40415097) ; MORI Shunsuke 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 研究員 (90733147)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 三次元バーテックスモデル / 器官形成 / バイオメカニクス

Outline of Final Research Achievements

This study aims to develop a method to simulate tissue morphogenesis based on experimentally observed morphological data using the 3D vertex model. Moreover, by comparing the in-vivo and in-silico deformation processes quantitatively, we predicted several key mechanisms to drive the tissue morphogenesis. First, we deloped the mathematical model of cell apoptosis based on the 3D vertex model framework. Next, by applying the developed model to the optic-cup morphogenesis, we qualitatively predicted the mechanisms of the tissue morphogenesis.

Free Research Field

バイオメカニクス