2016 Fiscal Year Final Research Report
Light-induced regulation of flagellar and ciliary motility by a novel photoreceptor protein
Project/Area Number |
15K14566
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Animal physiology/Animal behavior
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Research Institution | University of Tsukuba |
Principal Investigator |
INABA Kazuo 筑波大学, 生命環境系, 教授 (80221779)
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Co-Investigator(Renkei-kenkyūsha) |
SHIBA Kogiku 筑波大学, 生命環境系, 助教 (70533561)
HIROSE Keiko 国立研究開発法人産業総合研究所, バイオメディカル研究部門, 主任研究員 (90357872)
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Research Collaborator |
KUTOMI Osamu
JOKURA Kei
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | DYBLUP / ダイニン / BLUP / 光応答 / 鞭毛 / 繊毛 / 精子 / クラミドモナス |
Outline of Final Research Achievements |
This research project was carried out to clarify the molecular nature and mechanism of a novel dynein photoreceptor DYBLUP. The 2 years project showed (1) the molecule of f/I1 dynein form ascidian sperm is similar to that from Chlamydomonas flagella, (2) ascidian DYBLUP is bound to the motor region of f/I1, (3) the protein product of a gene (MOT7) orthologous to DYBLUP is also present in Chlamydomonas flagella, (5) a Chlamydomonas mutant lacking DYBLUP/MOT7 shows suppressed positive phototaxis and the turn movement in photoshock reaction.
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Free Research Field |
分子細胞生物学
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