2016 Fiscal Year Final Research Report
Elucidation of cellular uptake of curcumin: its relation to biological activity
| Project/Area Number |
15K14725
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | クルクミン / 生物学的利用能 / ナノ粒子 / 細胞内移行 / アルブミン |
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| Outline of Final Research Achievements |
Curcumin (CUR) has been known to have various biological activity, whereas bioavailability of CUR is low. It is still unclear whether CUR itself and/or metabolites are responsible for the biological activity in vivo. We hypothesized that preferential uptake of CUR by cultured cells determine its biological activity. To evaluate this, we performed cell culture studies. Using HPLC, it was revealed the uptake of CUR by cultural cells was high, whereas that of CUR related compounds was low. Hence, the remarkable differential cellular uptake of CUR, relative to the related compounds, would determine the biological activity of CUR. Our ongoing studies showed that the differential uptake may occur via interaction of CUR with a medium component, albumin. In addition, we are performing experiments about CUR nanoformulation in order to increase bioavailability of CUR. Our studies will provide a better understanding of the bioavailability and biological activity of CUR for nutraceutical purposes.
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| Free Research Field |
農芸化学・食品科学
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