• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2016 Fiscal Year Final Research Report

Analysis for nonalcoholic steatohepatitis development mechanism using focused microarray analysis aimed for elucidation of food effect.

Research Project

  • PDF
Project/Area Number 15K14726
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

Miyazawa Teruo  東北大学, 農学研究科, 教授 (20157639)

Project Period (FY) 2015-04-01 – 2017-03-31
Keywordsラット / フォーカストアレイ / 脂肪肝 / 過酸化脂質
Outline of Final Research Achievements

Fatty liver is a risk factor for steatohepatitis, hepatic cirrhosis and hepatoma, thus increasing nonalcoholic fatty liver disease related with obesity is becoming a problem. This study examined animal model and analysis method for the elucidation of the multifactorial mechanism leading nonalcoholic steatohepatitis development, and prevention by food component. Liver mRNA of rat examined by the focused microarray analysis. High fat diet fed rats with high value of serum liver disorder marker and fatty liver accompanied the increment of mRNA expression of cytokine related on initial stage of the inflammation, along with influence of several antioxidative enzymes. These results show the application possibility of focused microarray analysis on the investigation of nonalcoholic steatohepatitis development caused by the multifactorial mechanism. Further study will enable elucidation of steatohepatitis development mechanism.

Free Research Field

食品学

URL: 

Published: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi