Genetic polymorphism of bitter taste receptor TAS2R and hepatic detoxification enzyme GST.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K14728
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: Komai Michio 東北大学, 農学研究科, 教授 (80143022)
• Co-Investigator(Renkei-kenkyūsha): ISONO KUNIO 東北大学, 大学院農学研究科, 技術補佐員 (70124550)
• Research Collaborator: YAMAKI MICHIKO 東北生活文化大学, 助教
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 苦味受容体 / ＴＡＳ２Ｒ３８ / 消化器癌患者 / 健常者 / 苦味感受性 / グルタチオン-S トランスフェラーゼ（ＧＳＴ）

Outline of Final Research Achievements

The involvement of bitter taste receptor, TAS2Rs in cancers has not been well understood. So, we conducted a pilot study by genotyping two TAS2R genes, TAS2R38 and TAS2R46, in Japanese cancer patients diagnosed with the digestive cancer. As a results, we confirmed that phenylthiocarbamide (PTC) non-tasters homozygous (AVI/AVI) for TAS2R38 were more frequent among Japanese cancer patients than those among control subjects, which indicates that the AVI/AVI genotype for TAS2R38 was therefore considered to increase cancer risk.

Free Research Field

食品科学、栄養生理学