2016 Fiscal Year Final Research Report
Clarification of the role of myofibroblasts in cancer niche by development of cancer-tissue like organoid
| Project/Area Number |
15K14856
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Ohama Takashi 山口大学, 共同獣医学部, 准教授 (50579018)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | がん / 筋線維芽細胞 / 大腸癌 / HB-EGF |
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| Outline of Final Research Achievements |
Cancer microenvironment (cancer-niche) has been shown to contribute to the growth and malignant transformation of cancer. Accumulating evidences revealed that myofibroblasts plays the central role in cancer-niche. However, it remains largely unknown how myofibroblasts and cancer cells regulate each other. In this project, we found that HB-EGF secreted by cancer cells promotes myofibloblasts migration through ERK1/2 and JNK1/2 activation, which, in turn, could support cancer progression.
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| Free Research Field |
薬理学
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