2016 Fiscal Year Final Research Report
A neurotrophic role of extracellular poly (ADP-ribose) in neurological sdisorders
| Project/Area Number |
15K14857
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 薬理 / 神経科学 / シグナル伝達 / 脳神経疾患 / 獣医学 |
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| Outline of Final Research Achievements |
In this study, we investigated the role of extracellular poly(ADP-ribose) (EC-PAR) in the pathophysiology of neurodegenerative disorders. PAR is synthesized by PAR polymerase-1 (PARP-1) and released into the extracellular space during PARP-1-induced cell death. In vitro, treatment of rat astrocytes with EC-PAR increased the synthesis and release of glial cell line-derived neurotrophic factor (GDNF) but not other neurotrophic factors. In vivo, topical injection of EC-PAR into the striatum of a Parkinson disease rat model upregulated GDNF levels in activated astrocytes and improved pathogenic rotation behavior. Because GDNF is known to be neuroprotective in cases of Parkinson disease, administration of EC-PAR could potentially be used to treat this devastating disease.
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| Free Research Field |
獣医薬理
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